Brief Introduction

The Biological Genetic Resources Bank Working Committee of the Chinese Academy of Sciences aims to build the largest scientific preservation system of biological genetic resources with high scientific research value. The Biological Genetic Resources Bank Working Committee aims to promote the development and utilization resources through accelerating the investigation, collection, evaluation and function mining of biological genetic resources and provide high-quality biological genetic resources and high-level professional technical services for life science research, biotechnology innovation and industrial development of China.

  • 海藻种质库研发选育的优良海带品系
  • 中国西南野生生物种质资源库植物种子保藏设施


Biological Genetic Resources Bank Institution Director
Leading Unit
China General Microbiological Culture Collection Center Institute of Microbiology, Chinese Academy of Sciences XIANG Hua
Composing Members
Microorganism and Viruses Culture Collection Center Wuhan Institute of Virology, Chinese Academy of Sciences DENG Fei
The Germplasm Bank of Wild species Kunming Institute of Botany, Chinese Academy of Sciences YANG Xiangyun
Kunming Cell Bank Kunming Institute of Zoology, Chinese Academy of Sciences NAI Wenhui
Cell Bank and Stem Cell Bank Shanghai institute for Biological Sciences, Chinese Academy of Sciences CHEN Yuelei
Immortalize Cell Bank of Different Chinese Ethnic Groups Institute of Genetics and Developmental Biology, Chinese Academy of Sciences LIU Xi
Beijing Stem Cell Bank Institute of Zoology, Chinese Academy of Sciences HAO Jie
Freshwater Algae Culture Collection Institute of Hydrobiology, Chinese Academy of Sciences SONG Lirong
Marine Algae Stock Culture Collection Center Institute of Oceanology, Chinese Academy of Sciences PANG Shaojun
Tissue Bank of Wild Animals’ Infectious Diseases Institute of Zoology, Chinese Academy of Sciences HE Hongxuan
Transformation Bank of South China Stem Cell Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences DUAN Ziyuan
Human Resource Sample Bank Institute of Biophysics, Chinese Academy of Sciences LI Yan

Highlights of Work

  • Holdings Patent
    2010: 4,584

    Holdings of Biological Material for Patent over lastdecade

China General Microbiological Culture Collection Center (CGMCC) established in 1979, is a non-profit organization financed by the Chinese Academy of Sciences. It has been designated as a depository organization in China for patent purpose by Patent Bureau of China since 1985, and has served as an International Depository Authority (IDA) under the regulations of the Budapest Treaty since 1995. At present, CGMCC hosts 15215 items of biological materials for patent purpose, which is the second highest number of patent deposits among the 45 IDAs under Budapest Treaty. Including the microbial strains deposited in public collection of CGMCC, its collections currently comprise more than 61000 microorganisms which are composed of 2111 genera and 6183 species. And all these biological materials accepted in the CGMCC are subject to extensive quality control since CGMCC passed the audit conducted by China Quality Certification Center and acquired certificate for compliance with the standard ISO 9001 in 2010.

  • The identification of clinical-grade human embryonic stem cells and their derivatives

The Beijing Stem Cell Bank has established more than 500 clinical-grade cell lines, including more than 300 clinical-grade human embryonic stem cell lines, which can basically match the population of more than 70% HLA-A/B of the Han population. These cell lines conform to the criteria for clinical-grade stem cells made by international organizations, such as the ISSCR (International Society for Stem Cell Research) and ISCF (International Stem Cell Forum). In April 11, 2017, two Chinese stem cell clinical research projects — "neural precursor cells derived from human embryonic stem cells for the treatment of Parkinson's disease" and "retinal pigment epithelial cells derived from human embryonic stem cells for the treatment of dry age-related macular degeneration" were launched in China, which was recorded by the NHC (National Health Commission of the People’s Republic of China) and CFDA (China Food and Drug Administration). These have brought dawn to treat Parkinson's disease and age-related macular degeneration. It is also great significance to open up a new chapter for curing many refractory diseases.

  • A. Propagation lab, B. Outdoor tubular photo-bioreactors, C. Harvest workshops, D. Dry algal powder

China has been leading microalgae industry over 20 years in the world, with the steady increase in the global and domestic market. While Spirulina, a blue-green alga, remains as a major product in the market, Haematococcus, a green alga, is becoming a new focus in microalgal industry due to increasing demanding for its pigment such as astathanthin. Over the past 5 years, FACHB-Collection has been actively engaged in the selection and breeding of Haematococcus, obtaining several strains featured in fast growth and high content of astathanthin; Meanwhile, a set of protocols suitable for mass culture are developed and applied. Taking advantage of large collection of strains, a set of techniques and protocols for scale-up cultivation, we helped establishment of one of Haematococcus companies, named Qujing Bohao in Yunnan province. The administration and demonstration of the techniques and protocols in the large-scale production of Haematococcus has been contributing to the fast and healthy development in microalgal industry.

The Microorganisms & Viruses Culture Collection Center (MVCCC), Wuhan Institute of Virology (WIV), Chinese Academy of Sciences (CAS), has been officially authorized as one of the “National Culture Collection Center” by the National Health Commission of the People’s Republic of China in April 2018. Based on Wuhan's BSL-4 laboratory platform, the center is equipped and qualified to preserve the microorganisms and viruses of all biosafety grades, and will play significant roles in the fields of national security, life science research, public health and virology research.

For supporting the country's strategic demands, MVCCC responded promptly to the epidemic prevention of the recent outbreak of Zika virus (ZIKV), and success in isolation of a new strain of ZIKV and import of 27 strains from France, the United States, etc. MVCCC has been assigned as one of the distribution centers in China by the European Virus Archive goes global (EVAg) project. To date, more than 10 domestic research institutions have applied and obtained the ZIKV strains and related antibodies of up to 35 items from MVCCC. Meanwhile, MVCCC performed the phylogenetic analysis of ZIKV, which firstly discovered that the global ZIKV strains can be divided into three genotypes and revealed the geographic origins of ZIKV outbreaks and epidemics. These findings provide insights into further epidemiological studies of ZIKV, which is important for the prevention and control of ZIKV epidemics.

Representative pictures

  • 海藻种质库研发选育的优良海带品系
  • 中国西南野生生物种质资源库植物种子保藏设施